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Description for Protein AKR1B1

aldo-keto reductase family 1, member B1 (aldose reductase)
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(platelet: 4; secretome: 1)
Summary:
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.1.1.21
KEGG - Orthology:
K00011
KEGG - Pathway(s):
hsa00040; hsa00051; hsa00052; hsa00561; hsa00620; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
EC 1.1.1.21; Aldo-keto reductase family 1, member B1; Aldehyde reductase 1; AR; ALDR1
Approved Symbol:
AKR1B1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 4
Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID(db);
  • (5-CHLORO-2-{[(3-NITROBENZYL)AMINO]CARBONYL}PHENOXY)ACETIC ACID(db);
  • 2'-Monophosphoadenosine 5'-Diphosphoribose(db);
  • 2-(3-((4,5,7-trifluorobenzo[d]thiazol-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)acetic acid(db);
  • 2-(CARBOXYMETHYL)-1-OXO-1,2-DIHYDRONAPHTHO[1,2-D]ISOTHIAZOLE-4-CARBOXYLIC ACID 3,3-DIOXIDE(db);
  • 2[4-BROMO-2-FLUOROPHENYL)METHYL]-6-FLUOROSPIRO[ISOQUINOLINE-4-(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONE(db);
  • 3,4-DIHYDRO-4-OXO-3-((5-TRIFLUOROMETHYL-2-BENZOTHIAZOLYL)METHYL)-1-PHTHALAZINE ACETIC ACID(db);
  • 3-[5-(3-nitrophenyl)thiophen-2-yl]propanoic acid(db);
  • 4-[3-(3-NITROPHENYL)-1,2,4-OXADIAZOL-5-YL]BUTANOIC ACID(db);
  • 6-[(5-CHLORO-3-METHYL-1-BENZOFURAN-2-YL)SULFONYL]PYRIDAZIN-3(2H)-ONE(db);
  • Alpha-D-Glucose-6-Phosphate(db);
  • Alrestatin(db);
  • Citric Acid(db);
  • Fidarestat(db);
  • Fidarestat(Stereoisomer)(db);
  • Hydroxydimethylarsine Oxide(db);
  • IDD552(db);
  • IDD594(db);
  • Inhibitor Idd 384(db);
  • N-Acetylalanine(db);
  • NADH(db);
  • Sorbinil(db);
  • Sulindac(db);
  • Tolrestat(db);
  • [3-(4-Bromo-2-Fluoro-Benzyl)-7-Chloro-2,4-Dioxo-3,4-Dihydro-2h-Quinazolin-1-Yl]-Acetic Acid(db);
  • {3-[(4,5,7-TRIFLUORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-1H-INDOL-1-YL}ACETIC ACID(db);
  • {3-[(5-CHLORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL}ACETIC ACID(db);
  • {4-[(CARBOXYMETHOXY)CARBONYL]-3,3-DIOXIDO-1-OXONAPHTHO[1,2-D]ISOTHIAZOL-2(1H)-YL}ACETIC ACID(db);
  • {[5-(5-NITRO-2-FURYL)-1,3,4-OXADIAZOL-2-YL]THIO}ACETIC ACID(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00071 Entrez Gene ID: 231 OMIM ID: 103880 Swissprot Accession: P15121;