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Description for Protein IQSEC2

IQ motif and Sec7 domain 2
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 3)
Summary:
The IQSEC2 gene encodes a guanine nucleotide exchange factor for the ARF family of GTP-binding proteins (see, e.g., ARF1; MIM 103180) (Shoubridge et al., 2010 [PubMed 20473311]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • IQ: Short calmodulin-binding motif containing conserved Ile and Gln residues.
  • Sec7: Sec7 domain
  • PH: Pleckstrin homology domain.
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12495
    KEGG - Pathway(s):
    hsa04144
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    IQ motif and Sec7 domain-containing protein 2; KIAA0522; OTTHUMP00000061872
    Approved Symbol:
    IQSEC2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 10012 Entrez Gene ID: 23096 OMIM ID: 300522 Swissprot Accession: Q5JU85; Q5JUX1; B3KT97;