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Description for Protein FOXO3

forkhead box O3
33 total interacting proteins; 21 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • FH: FORKHEAD
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09408
    KEGG - Pathway(s):
    hsa04062; hsa04722; hsa05213; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Forkhead box O3A; FKHRL1; Forkhead in rhabdomyosarcoma like 1; AF6q21 protein; FKHRL1P2; MGC12739; MGC31925; DKFZp781A0677; Forkhead homolog (rhabdomyosarcoma) like 1
    Approved Symbol:
    FOXO3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 25
    Human (de-) phosphorylation sites: 25; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04061 Entrez Gene ID: 2309 OMIM ID: 602681 Swissprot Accession: O43524;