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Description for Protein KDM4C

lysine (K)-specific demethylase 4C
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • JMJC: A domain family that is part of the cupin metalloenzyme superfamily.
  • JmjN: Small domain found in the jumonji family of transcription factors
  • PHD: PHD zinc finger
  • TUDOR: Tudor domain
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.14.11.-
    KEGG - Orthology:
    K06709
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    GASC1; KIAA0780; bA146B14.1; Gene amplified in squamous cell carcinoma 1 protein
    Approved Symbol:
    KDM4C
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 12016 Entrez Gene ID: 23081 OMIM ID: 605469 Swissprot Accession: B4E1Y4; Q9H3R0; B4E239;