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Description for Protein PDS5B

PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein that interacts with the conserved protein complex termed cohesion. The cohesion complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • AT_hook: DNA binding domain with preference for A/T rich regions
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K11267
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    AS3; Androgen induced prostate proliferative shutoff associated protein; Androgen-induced prostate proliferative shutoff associated protein isoform 1
    Approved Symbol:
    PDS5B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 36
    Human (de-) phosphorylation sites: 36; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05624 Entrez Gene ID: 23047 OMIM ID: 605333 Swissprot Accession: Q9NTI5;