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Description for Protein TNIK

TRAF2 and NCK interacting kinase
6 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/1)
(phosphoproteome: 1; platelet: 2; undefined: 1)
Summary:
Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • CNH: Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K08840
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    EC 2.7.1.37; KIAA0551; AD 2
    Approved Symbol:
    TNIK
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 41
    Human (de-) phosphorylation sites: 41; Platelet phosphorylation sites: 6
    Phosphorylation Targets:
    Total phosphorylation targets: 7
    Human phosphorylation targets: 2; Predicted platelet targets: 5
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 18206 Entrez Gene ID: 23043 OMIM ID: 610005 Swissprot Accession: Q9UKE5;