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Description for Protein FOXE1

forkhead box E1 (thyroid transcription factor 2)
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This intronless gene belongs to the forkhead family of transcription factors, which is characterized by a distinct forkhead domain. This gene functions as a thyroid transcription factor which likely plays a crucial role in thyroid morphogenesis. Mutations in this gene are associated with congenital hypothyroidism and cleft palate with thyroid dysgenesis. The map localization of this gene suggests it may also be a candidate gene for squamous cell epithelioma and hereditary sensory neuropathy type I. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • FH: FORKHEAD
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09398
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Forkhead-related protein FKHL15; FKHL15; Forkhead box E1; Thyroid transcription factor 2; TTF2; TITF2; Forkhead, homolog like 15; FOXE2; HFKH4; HFKL5; Forkhead box E2; Forkhead-like 15; TTF-2
    Approved Symbol:
    FOXE1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04014 Entrez Gene ID: 2304 OMIM ID: 602617 Swissprot Accession: O00358;