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Description for Protein NT5C2

5'-nucleotidase, cytosolic II
6 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Purine 5-prime-nucleotidase (EC 3.1.3.5) preferentially hydrolyzes inosine 5-prime-monophosphate (IMP) and other purine nucleotides, and is allosterically activated by various compounds, including ATP. The enzyme is exclusively located in the cytoplasmic matrix of cells and may have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.1.3.5
KEGG - Orthology:
K01081
KEGG - Pathway(s):
hsa00230; hsa00240; hsa00760; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
GMP; NT5B; PNT5; cN II; 5 prime nucleotidase cytosolic type B; MP specific 5 prime NT; Purine 5 prime nucleotidase; EC 3.1.3.5
Approved Symbol:
NT5C2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 4
Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine triphosphate(db);
  • Ribavirin(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02686 Entrez Gene ID: 22978 OMIM ID: 600417 Swissprot Accession: P49902; A8K6K2;