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Description for Protein P2RX2

purinergic receptor P2X, ligand-gated ion channel, 2
4 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Six transcript variants encoding six distinct isoforms have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain

  • Gene Ontology:
    Gene Ontology Annotations

    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05216
    KEGG - Pathway(s):
    hsa04020; hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    P2X2; P2X purinoceptor 2; ATP receptor; Purinergic receptor P2X2; P2X receptor subunit 2; MGC129601; Purinergic receptor P2X2 isoform D; Purinergic receptor P2X2 isoform A; Purinergic receptor P2X2 isoform C; Purinergic receptor P2X2 isoform B; Purinergic receptor P2X2 isoform I; Purinergic receptor P2X2 isoform H
    Approved Symbol:
    P2RX2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites

    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available


    Associated Genetic Diseases:

    None Available
    Predicted Transmembrane Domains:
  • Isoform 6 : 2
  • Isoform 5 : 0
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 0
  • Isoform 1 : 1
  • Additional Identifiers:

    HPRD: 15984 Entrez Gene ID: 22953 OMIM ID: 600844 Swissprot Accession: Q9UBL9