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Description for Protein RPIA

ribose 5-phosphate isomerase A
7 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/1)
(microparticles: 1; platelet: 2; secretome: 1)
Summary:
The protein encoded by this gene is an enzyme, which catalyzes the reversible conversion between ribose-5-phosphate and ribulose-5-phosphate in the pentose-phosphate pathway. This gene is highly conserved in most organisms. The enzyme plays an essential role in the carbohydrate metabolism. Mutations in this gene cause ribose 5-phosphate isomerase deficiency. A pseudogene is found on chromosome 18. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
5.3.1.6
KEGG - Orthology:
K01807
KEGG - Pathway(s):
hsa00030; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Ribose 5 phosphate epimerase; RPI; Phosphoriboisomerase
Approved Symbol:
RPIA
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • D-4-Phosphoerythronic Acid(db)

    Associated Genetic Diseases:

  • Ribose 5-phosphate isomerase deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01589 Entrez Gene ID: 22934 OMIM ID: 180430 Swissprot Accession: P49247;