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Description for Protein SIRT2

sirtuin 2
23 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/2)
(phosphoproteome: 1; platelet: 14; undefined: 1)
Summary:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.5.1.-
KEGG - Orthology:
K11412
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
Sirtuin 2 isoform 1; SIR2L; SIR2L2; Sirtuin type 2; Sir2-related protein type 2; Silencing information regulator 2-like; EC 3.5.1.-; Sirtuin 2 isoform 2
Approved Symbol:
SIRT2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 14
Human (de-) phosphorylation sites: 14; Platelet phosphorylation sites: 2
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 10377 Entrez Gene ID: 22933 OMIM ID: 604480 Swissprot Accession: Q8IXJ6; C9JFD5;