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Description for Protein PLA2R1

phospholipase A2 receptor 1, 180kDa
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene represents a phospholipase A2 receptor. The encoded protein likely exists as both a transmembrane form and a soluble form. The transmembrane receptor may play a role in clearance of phospholipase A2, thereby inhibiting its action. Polymorphisms at this locus have been associated with susceptibility to idiopathic membranous nephropathy. Alternatively spliced transcript variants encoding different isoforms have been identified. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • LECTIN_C: C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
  • TM: Transmembrane domain
  • FN2: Fibronectin type 2 domain
  • RICIN: Ricin-type beta-trefoil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06560
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    CLEC13C; 180 kDa transmembrane PLA2 receptor; Phospholipase A2 receptor 1 isoform 2 precursor; Phospholipase A2 receptor 1 isoform 1 precursor; Phospholipase A2 receptor 1, 180kDa; Phospholipase A2 receptor 180kDa; PLA2R; PLA2IR; PLA2G1R
    Approved Symbol:
    PLA2R1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 09222 Entrez Gene ID: 22925 OMIM ID: 604939 Swissprot Accession: Q13018;