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Description for Protein FKBP3

FK506 binding protein 3, 25kDa
9 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(membrane: 1; platelet: 1; secretome: 1)
Summary:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a higher affinity for rapamycin than for FK506 and thus may be an important target molecule for immunosuppression by rapamycin. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
5.2.1.8
KEGG - Orthology:
K09570
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
FK506 binding protein, T cell, 25 kDa; Peptidyl prolyl cis trans isomerase; PPIase; Rotamase; 25 kDa FKBP; FKBP25; Rapamycin selective 25 kDa immunophilin
Approved Symbol:
FKBP3
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 8
Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Rapamycin Immunosuppressant Drug(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01743 Entrez Gene ID: 2287 OMIM ID: 186947 Swissprot Accession: Q00688;