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Description for Protein NLRP1

NLR family, pyrin domain containing 1
11 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • LRR: Leucine-rich repeats, outliers
  • CARD: Caspase recruitment domain
  • BBOX: B-Box-type zinc finger
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12798
    KEGG - Pathway(s):
    hsa04621
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Death effector filament forming CED4 like apoptosis protein; NAC alpha/beta/gamma/delta; Caspase recruitment domain protein 7; CARD7; DEFCAP; PP1044; KIAA0926; DEFCAP-L/S; NACHT, leucine rich repeat and PYD containing 1; Death effector filament-forming Ced-4-like apoptosis protein isoform 1; Death effector filament-forming Ced-4-like apoptosis protein isoform 3; Death effector filament-forming Ced-4-like apoptosis protein isoform 2; Death effector filament-forming Ced-4-like apoptosis protein isoform 4; Death effector filament-forming Ced-4-like apoptosis protein isoform 5; Nucleotide-binding domain and caspase recruitment domain; NAC; NACHT-, LRR- and PYD-containing protein 2
    Approved Symbol:
    NLRP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07364 Entrez Gene ID: 22861 OMIM ID: 606636 Swissprot Accession: Q9H5Z7; Q9C000;