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Description for Protein RASA3

RAS p21 protein activator 3
4 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 9/2)
(membrane: 2; microparticles: 1; phosphoproteome: 1; platelet: 5; secretome: 2; undefined: 2)
Summary:
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • C2: Protein kinase C conserved region 2 (CalB)
  • PH: Pleckstrin homology domain.
  • BTK: Bruton's tyrosine kinase Cys-rich motif
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12380
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    GTPase activating protein 1 family, inositol 1,3,4,5 tetrakisphosphate binding protein; GAP1(IP4BP); inositol 1,3,4,5 tetrakisphosphate binding protein; GTPase activating protein III
    Approved Symbol:
    RASA3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05537 Entrez Gene ID: 22821 OMIM ID: 605182 Swissprot Accession: Q14644;