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Description for Protein FKBP1B

FK506 binding protein 1B, 12.6 kDa
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 4)
Summary:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
5.2.1.8
KEGG - Orthology:
K09568
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
Rotamase; FK506 binding protein 1 like; FKBP1L; FKBP12.6; Peptidyl prolyl cis trans isomerase; PPiase; 12.6 kDa FKBP; Immunophilin FKBP12.6KBP; OTK4; FKBP9; PKBP1L; PPIase; FK506-binding protein 1B; Calstabin 2; FK506-binding protein 12.6; FK506-binding protein 1B isoform a; FK506-binding protein 1B isoform b; EC 5.2.1.8; Peptidyl-prolyl cis-trans isomerase 1B; Rotamase 1B; h-FKBP-12
Approved Symbol:
FKBP1B
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Rapamycin Immunosuppressant Drug(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02795 Entrez Gene ID: 2281 OMIM ID: 600620 Swissprot Accession: P68106;