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Description for Protein IKZF3

IKAROS family zinc finger 3 (Aiolos)
17 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ZNFC2: zinc finger
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09220
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    AIOLOS; Zinc finger protein Aiolos; Zinc finger protein, subfamily 1A, 3 (Aiolos) isoform 1; Zinc finger protein, subfamily 1A, 3 (Aiolos) isoform 4; Zinc finger protein, subfamily 1A, 3 (Aiolos) isoform 3; Zinc finger protein, subfamily 1A, 3 (Aiolos) isoform 2; Zinc finger protein, subfamily 1A, 3 (Aiolos) isoform 6; Zinc finger protein, subfamily 1A, 3 (Aiolos) isoform 5
    Approved Symbol:
    IKZF3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 12
    Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05869 Entrez Gene ID: 22806 OMIM ID: 606221 Swissprot Accession: Q9UKT9;