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Description for Protein FKBP1A

FK506 binding protein 1A, 12kDa
19 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/2)
(platelet: 3; undefined: 1)
Summary:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
5.2.1.8
KEGG - Orthology:
K09568
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
FKBP12; FK506 binding protein 1; FKBP1; FK506 binding protein 12; FK506 binding protein, T-cell 12 kDa; Protein kinase C inhibitor 2; PKCI2; Peptidyl-prolyl cis-trans isomerase; PPIase; Rotamase; 12 kDa FKBP; Immunophilin FKBP12; FK506 binding protein 1A, 12kDa; FKBP12C; EC 5.2.1.8; OTTHUMP00000029980
Approved Symbol:
FKBP1A
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • (21S)-1AZA-4,4-DIMETHYL-6,19-DIOXA-2,3,7,20-TETRAOXOBICYCLO[19.4.0] PENTACOSANE(db);
  • (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Leucine(db);
  • (3r)-4-(P-Toluenesulfonyl)-1,4-Thiazane-3-Carboxylicacid-L-Phenylalanine Ethyl Ester(db);
  • 4-Hydroxy-2-Butanone(db);
  • 6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine(db);
  • Dimethyl sulfoxide(db);
  • FKB-001(db);
  • Gpi-1046(db);
  • Heptyl-Beta-D-Glucopyranoside(db);
  • L-709,587(db);
  • Methyl Methylsulfinylmethyl Sulfide(db);
  • MYRISTIC ACID(db);
  • Pimecrolimus(db);
  • Rapamycin Immunosuppressant Drug(db);
  • Sirolimus(db);
  • Tacrolimus(db);
  • {3-[3-(3,4-Dimethoxy-Phenyl)-1-(1-{1-[2-(3,4,5-Trimethoxy-Phenyl)-Butyryl]-Piperidin-2yl}-Vinyloxy)-Propyl]-Phenoxy}-Acetic Acid(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01741 Entrez Gene ID: 2280 OMIM ID: 186945 Swissprot Accession: P62942; Q0VDC6;