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Description for Protein FGR

Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog
22 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH2: Src homology 2 domains
  • Tyr_Kinase: tyrosine kinase domain
  • SH3: Src homology 3 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.2
    KEGG - Orthology:
    K08891
    KEGG - Pathway(s):
    hsa04062
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Gardner Rasheed feline sarcoma viral oncogene homolog; Oncogene FGR; SRC2; c-fgr; p55c-fgr
    Approved Symbol:
    FGR
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 5
    Human phosphorylation targets: 5; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01288 Entrez Gene ID: 2268 OMIM ID: 164940 Swissprot Accession: P78453; P09769;