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Description for Protein FGG

fibrinogen gamma chain
11 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 17/2)
(alpha granules: 1; membrane: 2; microparticles: 1; platelet: 14; secretome: 4; undefined: 2)
Summary:
The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • CC: Coiled Coil
  • FBG: Fibrinogen-related domains (FReDs)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03905
    KEGG - Pathway(s):
    hsa04610
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Fibrinogen, gamma chain isoform gamma-A
    Approved Symbol:
    FGG
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Sucralfate(db)

    Associated Genetic Diseases:

  • Afibrinogenemia(Pd);
  • Fibrinogen Asahi(Pd);
  • Fibrinogen Baltimore 1(Pd);
  • Fibrinogen Baltimore 3(Pd);
  • Fibrinogen Baltimore 4(Pd);
  • Fibrinogen Bergamo 2(Pd);
  • Fibrinogen Giessen 4(Pd);
  • Fibrinogen Hillsborough(Pd);
  • Fibrinogen Kyoto 1(Pd);
  • Fibrinogen Kyoto 3(Pd);
  • Fibrinogen Matsumoto 1(Pd);
  • Fibrinogen Milano 1(Pd);
  • Fibrinogen Milano XII, digenic(Pd);
  • Fibrinogen Nagoya 1(Pd);
  • Fibrinogen Osaka 5(Pd);
  • Fibrinogen Paris 1(Pd);
  • Fibrinogen Vlissingen 1(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00621 Entrez Gene ID: 2266 OMIM ID: 134850 Swissprot Accession: P02679;