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Description for Protein ALDOA

aldolase A, fructose-bisphosphate
15 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 11/2)
(alpha granules: 1; membrane: 2; microparticles: 1; platelet: 8; secretome: 2; undefined: 1)
Summary:
This gene product, Aldolase A (fructose-bisphosphate aldolase) is a glycolytic enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Aldolase A is found in the developing embryo and is produced in even greater amounts in adult muscle. Aldolase A expression is repressed in adult liver, kidney and intestine and similar to aldolase C levels in brain and other nervous tissue. Aldolase A deficiency has been associated with myopathy and hemolytic anemia. Alternative splicing of this gene results in multiple transcript variants which encode the same protein. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
4.1.2.13
KEGG - Orthology:
K01623
KEGG - Pathway(s):
hsa00010; hsa00030; hsa00051; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Aldolase A, Fructose-bisphosphate; Fructose 1,6-bisphosphate aldolase A; Aldolase A; ALDA; Fructoaldolase A; EC 4.1.2.13
Approved Symbol:
ALDOA
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 16
Human (de-) phosphorylation sites: 16; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1,3-Dihydroxyacetonephosphate(db);
  • 1,6-DI-O-PHOSPHONO-D-MANNITOL(db);
  • 1,6-Fructose Diphosphate (Linear Form)(db);
  • N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE(db)

    Associated Genetic Diseases:

  • Aldolase deficiency of red cells(Pd);
  • Myopathy and hemolytic anemia(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00070 Entrez Gene ID: 226 OMIM ID: 103850 Swissprot Accession: P04075;