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Description for Protein FGF2

fibroblast growth factor 2 (basic)
29 total interacting proteins; 15 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members bind heparin and possess broad mitogenic and angiogenic activities. This protein has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for this gene contains multiple polyadenylation sites, and is alternatively translated from non-AUG (CUG) and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • FGF: Acidic and basic fibroblast growth factor family.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04358
    KEGG - Pathway(s):
    hsa04010; hsa04810; hsa05200; hsa05218
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Fibroblast growth factor, basic; FGF; BHBGF 2; Heparin binding growth factor 2; HBGF 2; BFGF; Prostatropin
    Approved Symbol:
    FGF2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1,4-Dideoxy-5-Dehydro-O2-Sulfo-Glucuronic Acid(db);
  • 1,4-Dideoxy-O2-Sulfo-Glucuronic Acid(db);
  • Beta-Mercaptoethanol(db);
  • N,O6-Disulfo-Glucosamine(db);
  • Pentosan Polysulfate(db);
  • Sirolimus(db);
  • Sucralfate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00622 Entrez Gene ID: 2247 OMIM ID: 134920 Swissprot Accession: P09038;