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Description for Protein FGF1

fibroblast growth factor 1 (acidic)
15 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • FGF: Acidic and basic fibroblast growth factor family.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04358
    KEGG - Pathway(s):
    hsa04010; hsa04810; hsa05200; hsa05218
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Endothelial cell growth factor; ECGF; Heparin bindidng growth factor 1; HBGF1; Fibroblast growth factor, acidic; FGFA; Endothelial cell growth factor, alpha; ECGFA; Endothelial cell growth factor, beta; ECGFB; Acidic fibroblast growth factor; AFGF; Beta endothelial cell growth factor; ECGF beta
    Approved Symbol:
    FGF1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 5-AMINO-NAPHTALENE-2-MONOSULFONATE(db);
  • Amlexanox(db);
  • Formic Acid(db);
  • N,O6-Disulfo-Glucosamine(db);
  • Naphthalene Trisulfonate(db);
  • O2-Sulfo-Glucuronic Acid(db);
  • Pentosan Polysulfate(db);
  • Sucrose Octasulfate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00567 Entrez Gene ID: 2246 OMIM ID: 131220 Swissprot Accession: P05230; Q16089;