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Description for Protein FGB

fibrinogen beta chain
9 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 14/2)
(alpha granules: 1; cAMP/cGMP binding: 1; membrane: 2; microparticles: 1; platelet: 8; secretome: 2; undefined: 2)
Summary:
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • CC: Coiled Coil
  • FBG: Fibrinogen-related domains (FReDs)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03904
    KEGG - Pathway(s):
    hsa04610
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    -
    Approved Symbol:
    FGB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Sucralfate(db)

    Associated Genetic Diseases:

  • Afibrinogenemia, congenital(Pd);
  • Fibrinogen Baltimore 2(Pd);
  • Fibrinogen Christchurch 2(Pd);
  • Fibrinogen Ise(Pd);
  • Fibrinogen Longmont(Pd);
  • Fibrinogen Naples(Pd);
  • Fibrinogen New York 1(Pd);
  • Fibrinogen Nijmegen(Pd);
  • Fibrinogen, beta-148 polymorphism(Pd);
  • Fibrinogen-beta polymorphism(Pd);
  • Hypofibrinogenemia, congenital(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00620 Entrez Gene ID: 2244 OMIM ID: 134830 Swissprot Accession: P02675;