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Description for Protein FGA

fibrinogen alpha chain
17 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 14/3)
(alpha granules: 1; membrane: 1; microparticles: 1; phosphoproteome: 1; platelet: 11; secretome: 5; undefined: 2)
Summary:
The protein encoded by this gene is the alpha component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia, afibrinogenemia and renal amyloidosis. Alternative splicing results in two isoforms which vary in the carboxy-terminus. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • CC: Coiled Coil
  • FBG: Fibrinogen-related domains (FReDs)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03903
    KEGG - Pathway(s):
    hsa04610
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Fibrinogen, alpha polypeptide isoform alpha-E preproprotein; Fibrinogen, alpha polypeptide isoform alpha preproprotein
    Approved Symbol:
    FGA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 15
    Human (de-) phosphorylation sites: 15; Platelet phosphorylation sites: 5
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alpha-D-Mannose(db);
  • Alteplase(db);
  • Anistreplase(db);
  • Reteplase(db);
  • Sucralfate(db);
  • Tenecteplase(db)

    Associated Genetic Diseases:

  • Afibrinogenemia, congenital(Pd);
  • Amyloidosis, renal(Pd);
  • Fibrinogen Aarhus 1(None);
  • Fibrinogen Amiens 1(Pd);
  • Fibrinogen Bergamo 1(Pd);
  • Fibrinogen Canterbury(Pd);
  • Fibrinogen Caracas-2(Pd);
  • Fibrinogen Detroit 1(Pd);
  • Fibrinogen Dusart(Pd);
  • Fibrinogen Keokuk(Pd);
  • Fibrinogen Kyoto 2(Pd);
  • Fibrinogen Lima(Pd);
  • Fibrinogen Marburg(Pd);
  • Fibrinogen Nieuwegein(Pd);
  • Fibrinogen Rouen 1(Pd);
  • Hypodysfibrinogenemia, congenital(Pd);
  • Venous thromboembolism, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00619 Entrez Gene ID: 2243 OMIM ID: 134820 Swissprot Accession: P02671;