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Description for Protein ALDH3A2

aldehyde dehydrogenase 3 family, member A2
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(membrane: 2; platelet: 1)
Summary:
Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.2.1.3
    KEGG - Orthology:
    K00128
    KEGG - Pathway(s):
    hsa00010; hsa00053; hsa00071; hsa00280; hsa00310; hsa00330; hsa00340; hsa00380; hsa00410; hsa00561; hsa00620; hsa00640; hsa00650; hsa00903; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Aldehyde dehydrogenase family 3 subfamily A member 2; Aldehyde dehydrogenase 3 family member A2; ALDH10; FALDH; Aldehyde dehydrogenase microsomal; SLS; Aldehyde Dehydrogenase 10; Aldehyde dehydrogenase 3A2; EC 1.2.1.3; Aldehyde dehydrogenase 3A2 isoform 2; Aldehyde dehydrogenase 3A2, isoform 1; Aldehyde dehydrogenase 3A2 isoform 1
    Approved Symbol:
    ALDH3A2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • NADH(db)

    Associated Genetic Diseases:

  • Sjogren-Larsson syndrome(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 07188 Entrez Gene ID: 224 OMIM ID: 609523 Swissprot Accession: P51648; Q6I9T3;