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Description for Protein FDPS

farnesyl diphosphate synthase
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 1; secretome: 1)
Summary:
This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.5.1.1; 2.5.1.10
    KEGG - Orthology:
    K00787
    KEGG - Pathway(s):
    hsa00900; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    FPP synthetase; FPS; Farnesyl diphosphate synthetase; EC 2.5.1.1; EC 2.5.1.10
    Approved Symbol:
    FDPS
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-Hydroxy-2-(3-Pyridinyl)Ethylidene Bis-Phosphonic Acid(db);
  • Alendronate(db);
  • Dimethylallyl Diphosphate(db);
  • FARNESYL DIPHOSPHATE(db);
  • Geranyl Diphosphate(db);
  • GERANYLGERANYL DIPHOSPHATE(db);
  • Ibandronate(db);
  • ISOPENTENYL PYROPHOSPHATE(db);
  • Isopentyl Pyrophosphate(db);
  • Pamidronate(db);
  • Risedronate(db);
  • Zoledronate(db);
  • [1-HYDROXY-3-(METHYL-PENTYL-AMINO)-1-PHOSPHONO-PROPYL]-PHOSPHONIC ACID(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 2
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00606 Entrez Gene ID: 2224 OMIM ID: 134629 Swissprot Accession: P14324;