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Description for Protein PRPS1L1

phosphoribosyl pyrophosphate synthetase 1-like 1
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(microparticles: 1; platelet: 2)
Summary:
This intronless gene is specifically expressed in the testis, and encodes a protein that is highly homologous to the two subunits of phosphoribosylpyrophosphate synthetase encoded by human X-linked genes, PRPS1 and PRPS2. These enzymes convert pyrimidine, purine or pyridine bases to the corresponding ribonucleoside monophosphates. In vitro transcription/translation and site-directed mutagenesis studies indicate that translation of this mRNA initiates exclusively at a non-AUG (ACG) codon. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.7.6.1
KEGG - Orthology:
K00948
KEGG - Pathway(s):
hsa00030; hsa00230; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Ribose-phosphate pyrophosphokinase III; Phosphoribosyl pyrophosphate synthetase III; PRS-III; PRPS3; PRPSL; EC 2.7.6.1
Approved Symbol:
PRPS1L1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 17914 Entrez Gene ID: 221823 OMIM ID: 611566 Swissprot Accession: P21108;