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Description for Protein FCGR3A

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
12 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • IG: Immunoglobulin
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06463
    KEGG - Pathway(s):
    hsa04650; hsa04666; hsa05140; hsa05322
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Fc fragment of IgG, low affinity IIIa, receptor for; FCGR3; Immunoglobulin G Fc receptor III; IGFR3; Neutrophil antigen NA; Neutrophil specific antigen NC1; Neutrophil specific antigen NA2; Low affinity immunoglobulin gamma FC region receptor III-A; IGG FC receptor III-2; FC-gamma RIII-alpha; FC-gamma RIIIA; FCRIIIA; FC-gamma RIII; FCRIII; CD16-A; FCR-10
    Approved Symbol:
    FCGR3A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 1
    Human phosphorylation targets: 1; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Abciximab(db);
  • Adalimumab(db);
  • Alefacept(db);
  • Alemtuzumab(db);
  • Basiliximab(db);
  • Bevacizumab(db);
  • Cetuximab(db);
  • Daclizumab(db);
  • Efalizumab(db);
  • Etanercept(db);
  • Gemtuzumab ozogamicin(db);
  • Ibritumomab(db);
  • Intravenous Immunoglobulin(db);
  • Muromonab(db);
  • Natalizumab(db);
  • Palivizumab(db);
  • Rituximab(db);
  • Tositumomab(db);
  • Trastuzumab(db)

    Associated Genetic Diseases:

  • Neutrophil-specific antigens NA1/NA2(Pd);
  • Viral infections, recurrent, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 1
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00903 Entrez Gene ID: 2214 OMIM ID: 146740 Swissprot Accession: P08637;