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Description for Protein FCGR2B

Fc fragment of IgG, low affinity IIb, receptor (CD32)
14 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • IGC2: Immunoglobulin C-2 Type
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12560
    KEGG - Pathway(s):
    hsa04662; hsa04666; hsa05322
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Fc fragment of IgG low affinity IIb receptor for (CD32); CD32B; Low affinity immunoglobulin gamma Fc region receptor II-b; FcRII-b; IgG Fc receptor II-b; CD32 antigen; FCG2; IGFR2; CDW32; Fc fragment of IgG, low affinity IIb, receptor for (CD32) isoform 2; Fc fragment of IgG, low affinity IIb, receptor for (CD32) isoform 3; Fc fragment of IgG, low affinity IIb, receptor for (CD32) isoform 4; Fc fragment of IgG, low affinity IIb, receptor for (CD32) isoform 1
    Approved Symbol:
    FCGR2B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 10
    Human (de-) phosphorylation sites: 10; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Abciximab(db);
  • Adalimumab(db);
  • Alefacept(db);
  • Alemtuzumab(db);
  • Antithymocyte globulin(db);
  • Basiliximab(db);
  • Bevacizumab(db);
  • Cetuximab(db);
  • Daclizumab(db);
  • Efalizumab(db);
  • Etanercept(db);
  • Gemtuzumab ozogamicin(db);
  • Ibritumomab(db);
  • Intravenous Immunoglobulin(db);
  • Muromonab(db);
  • Natalizumab(db);
  • Palivizumab(db);
  • Rituximab(db);
  • Tositumomab(db);
  • Trastuzumab(db)

    Associated Genetic Diseases:

  • Systemic lupus erythematosus, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 06849 Entrez Gene ID: 2213 OMIM ID: 604590 Swissprot Accession: P31994;