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Description for Protein MARCH8

membrane-associated ring finger (C3HC4) 8
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • RINGv: The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins. Some of these proteins have been shown both in vivo and in vitro to have ubiquitin E3 ligase activity.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.3.2.19
    KEGG - Orthology:
    K10663
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    MIR; c MIR; RNF178; MARCH VIII; Cellular modulator of immune recognition OTTHUMP00000058921; Membrane-associated RING-CH protein VIII; c-Mir, cellular modulator of immune recognition; Cellular modulator of immune recognition (c-MIR); Cellular modulator of immune recognition isoform 8; Cellular modulator of immune recognition isoform 7; Cellular modulator of immune recognition isoform 6
    Approved Symbol:
    MARCH8
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 2
  • Isoform 2 : 2
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 17466 Entrez Gene ID: 220972 OMIM ID: - Swissprot Accession: Q5T0T0;