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Description for Protein FCGR1A

Fc fragment of IgG, high affinity Ia, receptor (CD64)
11 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
This gene encodes a protein that plays an important role in the immune response. This protein is a high-affinity Fc-gamma receptor. The gene is one of three related gene family members located on chromosome 1. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • Ig_LIKE: Immunoglobulin like
  • IGC2: Immunoglobulin C-2 Type
  • TM: Transmembrane domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06498
    KEGG - Pathway(s):
    hsa04640; hsa04666; hsa05140; hsa05322
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    High affinity immunoglobulin gamma Fc receptor I; FcRI; IgG Fc receptor I CD64; FCG1; Immunoglobulin G Fc Receptor I; Fc fragment of IgG, high affinity Ia, Receptor; IGFR1; CD64
    Approved Symbol:
    FCGR1A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Abciximab(db);
  • Adalimumab(db);
  • Alefacept(db);
  • Alemtuzumab(db);
  • Basiliximab(db);
  • Bevacizumab(db);
  • Cetuximab(db);
  • Daclizumab(db);
  • Efalizumab(db);
  • Etanercept(db);
  • Gemtuzumab ozogamicin(db);
  • Ibritumomab(db);
  • Intravenous Immunoglobulin(db);
  • Methyl aminolevulinate(db);
  • Muromonab(db);
  • Natalizumab(db);
  • Palivizumab(db);
  • Porfimer(db);
  • Rituximab(db);
  • Tositumomab(db);
  • Trastuzumab(db)

    Associated Genetic Diseases:

  • IgG receptor I, phagocytic, familial deficiency of(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00904 Entrez Gene ID: 2209 OMIM ID: 146760 Swissprot Accession: P12314;