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Description for Protein FCER1G

Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
8 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 5/3)
(membrane: 1; phosphoproteome: 1; platelet: 4; undefined: 2)
Summary:
The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • ITAM: Immunoreceptor tyrosine-based activation motif
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07983
    KEGG - Pathway(s):
    hsa04650; hsa04664; hsa05310
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Immunoglobin E receptor, high-affinity, of mast cells, gamma; Fc fragment of IgE, high affinity I, receptor for, gamma subunit; High affinity immunoglobulin epsilon receptor gamma-subunit; Fc-epsilon RI-gamma; FcERI
    Approved Symbol:
    FCER1G
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; Platelet phosphorylation sites: 2
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Benzylpenicilloyl Polylysine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00916 Entrez Gene ID: 2207 OMIM ID: 147139 Swissprot Accession: P30273;