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Description for Protein MS4A2

membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)
9 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of family members. (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08090
    KEGG - Pathway(s):
    hsa04664; hsa05310
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Membrane spanning 4 domains, subfamily A member 2; High affinity immunoglobulin epsilon receptor beta subunit; FcERI; IgE Fc receptor, beta subunit; Fc epsilon receptor I beta chain; Fc fragment of IgE, high affinity I, receptor for, beta subunit; Immunoglobulin E receptor, high affinity, beta polypeptide; Fc IgE receptor, beta chain
    Approved Symbol:
    MS4A2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Omalizumab(db)

    Associated Genetic Diseases:

  • Atopic asthma, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 4
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 00915 Entrez Gene ID: 2206 OMIM ID: 147138 Swissprot Accession: Q01362; C9JE66;