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Description for Protein FBP1

fructose-1,6-bisphosphatase 1
10 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
Fructose-1,6-bisphosphatase 1, a gluconeogenesis regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. Fructose-1,6-diphosphatase deficiency is associated with hypoglycemia and metabolic acidosis. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
3.1.3.11
KEGG - Orthology:
K03841
KEGG - Pathway(s):
hsa00010; hsa00030; hsa00051; hsa01100; hsa04910
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Fructose-1,6-bisphosphatase 1; Fructose-1,6-diphosphatase
Approved Symbol:
FBP1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2,5-Anhydroglucitol-1,6-Biphosphate(db);
  • 2,5-DICHLORO-N-(5-CHLORO-1,3-BENZOXAZOL-2-YL)BENZENESULFONAMIDE(db);
  • 2,5-DICHLORO-N-[5-METHOXY-7-(6-METHOXYPYRIDIN-3-YL)-1,3-BENZOXAZOL-2-YL]BENZENESULFONAMIDE(db);
  • 4-AMINO-N-[(2-SULFANYLETHYL)CARBAMOYL]BENZENESULFONAMIDE(db);
  • Adenosine monophosphate(db);
  • Fructose-6-Phosphate(db);
  • Mdl-29951(db);
  • N-[7-(3-AMINOPHENYL)-5-METHOXY-1,3-BENZOXAZOL-2-YL]-2,5-DICHLOROBENZENESULFONAMIDE(db);
  • {4-[3-(6,7-Diethoxy-Quinazolin-4-Ylamino)-Phenyl]-Thiazol-2-Yl}-Methanol(db)

    Associated Genetic Diseases:

  • Fructose-1,6-bisphosphatase deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01973 Entrez Gene ID: 2203 OMIM ID: 611570 Swissprot Accession: Q2TU34; P09467;