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Description for Protein FASN

fatty acid synthase
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/0)
(membrane: 1; microparticles: 1; platelet: 1; secretome: 1)
Summary:
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.3.1.85
KEGG - Orthology:
K00665
KEGG - Pathway(s):
hsa00061; hsa01100; hsa04910
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
FAS
Approved Symbol:
FASN
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 21
Human (de-) phosphorylation sites: 21; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Cerulenin(db);
  • Orlistat(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02567 Entrez Gene ID: 2194 OMIM ID: 600212 Swissprot Accession: P49327;