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Description for Protein PTK2B

PTK2B protein tyrosine kinase 2 beta
74 total interacting proteins; 46 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/2)
(phosphoproteome: 1; undefined: 2)
Summary:
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • B41: Band 4.1 homologues
  • Tyr_Kinase: tyrosine kinase domain
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.2
    KEGG - Orthology:
    K05871
    KEGG - Pathway(s):
    hsa04020; hsa04062; hsa04650; hsa04670; hsa04912
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Focal adhesion kinase 2; CAK beta; Protein kinase B; Cell adhesion kinase beta; Proline-rich tyrosine kinase 2; Protein tyrosine kinase 2 beta; Calcium-dependent tyrosine kinase; PKB; PTK; CAKB; FAK2; PYK2; CADTK; FADK2; RAFTK; EC 2.7.1.112; PTK2B protein tyrosine kinase 2 beta isoform a; PTK2B protein tyrosine kinase 2 beta isoform b; Related adhesion focal tyrosine kinase
    Approved Symbol:
    PTK2B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 50
    Human (de-) phosphorylation sites: 50; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 5
    Human phosphorylation targets: 5; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide(db);
  • Genistein(db);
  • Leflunomide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03131 Entrez Gene ID: 2185 OMIM ID: 601212 Swissprot Accession: Q14289; Q6PID4;