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Description for Protein ACSL4

acyl-CoA synthetase long-chain family member 4
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(membrane: 1; platelet: 8)
Summary:
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.2.1.3
    KEGG - Orthology:
    K01897
    KEGG - Pathway(s):
    hsa00071; hsa01100; hsa03320; hsa04146; hsa04920
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Long chain fatty acid CoA ligase 4; Acyl CoA synthetase 4; ACS4; Fatty acid CoA ligase long chain 4; LACS4; Fatty acid thiokinase; Long chain acyl CoA synthetase 4; Lignoceroyl CoA synthase; FACL4; MRX63; EC 6.2.1.3; LACS 4; Acyl CoA synthetase long chain family member 4 isoform 1; Acyl CoA synthetase long chain family member 4 isoform 2
    Approved Symbol:
    ACSL4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 14
    Human (de-) phosphorylation sites: 14; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Icosapent(db);
  • Rosiglitazone(db);
  • Troglitazone(db)

    Associated Genetic Diseases:

  • Mental retardation, X-linked 63(Pd);
  • Mental retardation, X-linked 68(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 02152 Entrez Gene ID: 2182 OMIM ID: 300157 Swissprot Accession: O60488; Q5JWV8;