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Description for Protein ACSL3

acyl-CoA synthetase long-chain family member 3
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(membrane: 1; platelet: 4)
Summary:
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.2.1.3
    KEGG - Orthology:
    K01897
    KEGG - Pathway(s):
    hsa00071; hsa01100; hsa03320; hsa04146; hsa04920
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Fatty acid CoA ligase long chain 3; Long chain fatty acid CoA ligase 3; Long chain acyl CoA synthetase 3; LACS 3; Acyl CoA synthetase 3; ACS3; FACL3; PRO2194; Lignoceroyl-CoA synthase; Fatty-acid-Coenzyme A ligase, long-chain 3; EC 6.2.1.3; LACS3
    Approved Symbol:
    ACSL3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Icosapent(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 03845 Entrez Gene ID: 2181 OMIM ID: 602371 Swissprot Accession: B3KMA6; O95573;