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Description for Protein ALDH2

aldehyde dehydrogenase 2 family (mitochondrial)
11 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.2.1.3
KEGG - Orthology:
K00128
KEGG - Pathway(s):
hsa00010; hsa00053; hsa00071; hsa00280; hsa00310; hsa00330; hsa00340; hsa00380; hsa00410; hsa00561; hsa00620; hsa00640; hsa00650; hsa00903; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
ALDH, liver mitochondrial; Aldehyde dehydrogenase 2, family; ALDH class 2; ALDH-E2; ALDM; ALDHI; DHAM; EC 1.2.1.3
Approved Symbol:
ALDH2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 3
Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Crotonaldehyde(db);
  • Daidzin(db);
  • Disulfiram(db);
  • Guanidine(db);
  • NADH(db);
  • Nicotinamide-Adenine-Dinucleotide(db)

    Associated Genetic Diseases:

  • Alcohol sensitivity, acute(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00003 Entrez Gene ID: 217 OMIM ID: 100650 Swissprot Accession: P05091;