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Description for Protein F13A1

coagulation factor XIII, A1 polypeptide
7 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 13/2)
(alpha granules: 2; cAMP/cGMP binding: 1; membrane: 2; microparticles: 1; platelet: 9; secretome: 1; undefined: 1)
Summary:
This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TGC: Transglutaminase/protease-like homologues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.3.2.13
    KEGG - Orthology:
    K03917
    KEGG - Pathway(s):
    hsa04610
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Fibrin stabilizing factor subunit A; FSF; Fibrinologase; Protein-glutamine gamma -glutamyltransferase; TGase; F13A; bA525O21.1; EC 2.3.2.13; Transglutaminase A chain
    Approved Symbol:
    F13A1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1,2-Propanediol(db);
  • L-Glutamine(db);
  • N-Acetyl-Serine(db)

    Associated Genetic Diseases:

  • Factor XIII, A subunit, deficiency of(Pd);
  • Factor XIII, A subunit, polymorphism of(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00604 Entrez Gene ID: 2162 OMIM ID: 134570 Swissprot Accession: P00488;