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Description for Protein F8

coagulation factor VIII, procoagulant component
14 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03899
    KEGG - Pathway(s):
    hsa04610
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Coagulation factor VIII, procoagulant component (hemophilia A); Preprocoagulation factor VIII:C; Coagulation factor VIII, procoagulant component; Coagulation factor VIIIc, procoagulant component; AHF; F8B; HEMA; FVIII; DXS1253E; Factor VIII F8B; OTTHUMP00000061446; Antihemophilic factor; Coagulation factor VIII isoform b precursor; F8C; Coagulation factor VIII isoform a
    Approved Symbol:
    F8
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Coagulation Factor IX(db);
  • Drotrecogin alfa(db)

    Associated Genetic Diseases:

  • Factor VIII (Okayama)(Pd);
  • Factor VIII polymorphism(Pd);
  • Hemophilia A(Pd);
  • Hemophilia A, severe(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02384 Entrez Gene ID: 2157 OMIM ID: 306700 Swissprot Accession: P00451; Q14286;