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Description for Protein F5

coagulation factor V (proaccelerin, labile factor)
12 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 9/1)
(alpha granules: 1; membrane: 1; microparticles: 1; phosphoproteome: 1; platelet: 5; secretome: 2; undefined: 1)
Summary:
This gene encodes an essential cofactor of the blood coagulation cascade. This factor circulates in plasma, and is converted to the active form by the release of the activation peptide by thrombin during coagulation. This generates a heavy chain and a light chain which are held together by calcium ions. The activated protein is a cofactor that participates with activated coagulation factor X to activate prothrombin to thrombin. Defects in this gene result in either an autosomal recessive hemorrhagic diathesis or an autosomal dominant form of thrombophilia, which is known as activated protein C resistance. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03902
    KEGG - Pathway(s):
    hsa04610
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Factor V; Protein C cofactor; PCCF; Activated protein C; APC
    Approved Symbol:
    F5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 11
    Human (de-) phosphorylation sites: 11; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Drotrecogin alfa(db);
  • Phenylmercury(db)

    Associated Genetic Diseases:

  • Factor V Cambridge(Pd);
  • Factor V deficiency(Pd);
  • Factor V deficiency, hemorrhagic diathesis due to(Pd);
  • Factor V deficiency, severe(Pd);
  • Thrombophilia(Pd);
  • Thrombophilia due to deficiency of cofactor for activated protein c, Leiden type(Pd);
  • Thrombophilia due to deficiency of cofactor for activated protein c, liverpool type(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01964 Entrez Gene ID: 2153 OMIM ID: 612309 Swissprot Accession: P12259;