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Description for Protein F2

coagulation factor II (thrombin)
41 total interacting proteins; 27 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(alpha granules: 1; membrane: 1; secretome: 2)
Summary:
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • GLA: Domain containing Gla (gamma-carboxyglutamate) residues.
  • TRYPSIN: Trypsin-like serine protease
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.21.5
    KEGG - Orthology:
    K01313
    KEGG - Pathway(s):
    hsa04080; hsa04610; hsa04810
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Coagulation factor II; Factor II; Thrombin
    Approved Symbol:
    F2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2R)-2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}PROPENE-1-SULFONAMIDE(db);
  • (3ASR,4RS,8ASR,8BRS)-4-(2-(4-FLUOROBENZYL)-1,3-DIOXODEACAHYDROPYRROLO[3,4-A] PYRROLIZIN-4-YL)BENZAMIDINE(db);
  • (3R)-8-(dioxidosulfanyl)-3-methyl-1,2,3,4-tetrahydroquinoline(db);
  • (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexylamino)ethanoyl)pyrrolidine-2-carboxamide(db);
  • (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclohexyloxy)ethanoyl)pyrrolidine-2-carboxamide(db);
  • (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentylamino)ethanoyl)pyrrolidine-2-carboxamide(db);
  • (S)-N-(4-carbamimidoylbenzyl)-1-(2-(cyclopentyloxy)ethanoyl)pyrrolidine-2-carboxamide(db);
  • (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclohexylpropanoyl)pyrrolidine-2-carboxamide(db);
  • (S)-N-(4-carbamimidoylbenzyl)-1-(3-cyclopentylpropanoyl)pyrrolidine-2-carboxamide(db);
  • 1-(2-{[(6-AMINO-2-METHYLPYRIDIN-3-YL)METHYL]AMINO}ETHYL)-6-CHLORO-3-[(2,2-DIFLUORO-2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL(db);
  • 1-(HYDROXYMETHYLENEAMINO)-8-HYDROXY-OCTANE(db);
  • 1-butanoyl-N-(4-carbamimidoylbenzyl)-L-prolinamide(db);
  • 1-ETHOXYCARBONYL-D-PHE-PRO-2(4-AMINOBUTYL)HYDRAZINE(db);
  • 1-GUANIDINO-4-(N-NITRO-BENZOYLAMINO-L-LEUCYL-L-PROLYLAMINO)BUTANE(db);
  • 1-GUANIDINO-4-(N-PHENYLMETHANESULFONYL-L-LEUCYL-L-PROLYLAMINO)BUTANE(db);
  • 1-[(2R)-2-aminobutanoyl]-N-(3-chlorobenzyl)-L-prolinamide(db);
  • 1-[(2R)-2-aminobutanoyl]-N-(4-carbamimidoylbenzyl)-L-prolinamide(db);
  • 1-[2-AMINO-2-CYCLOHEXYL-ACETYL]-PYRROLIDINE-3-CARBOXYLIC ACID 5-CHLORO-2-(2-ETHYLCARBAMOYL-ETHOXY)-BENZYLAMIDE(db);
  • 2-(2-HYDROXY-BIPHENYL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE(db);
  • 2-(2-Hydroxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine(db);
  • 2-(3-CHLORO-6-{[2,2-DIFLUORO-2-(1-OXIDOPYRIDIN-2-YL)ETHYL]AMINO}-1-OXIDOPYRIDIN-2-YL)-N-[1-(3-CHLOROPHENYL)ETHYL]ACETAMIDE(db);
  • 2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHANESULFONAMIDE(db);
  • 2-(5-CHLORO-2-THIENYL)-N-{(3S)-1-[(1S)-1-METHYL-2-MORPHOLIN-4-YL-2-OXOETHYL]-2-OXOPYRROLIDIN-3-YL}ETHENESULFONAMIDE(db);
  • 2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(1-OXIDO-2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUOROPHENYL)METHYL]ACETAMIDE(db);
  • 2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUORO-3-METHYL-6-PYRIDINYL)METHYL]ACETAMIDE(db);
  • 2-(6-CHLORO-3-{[2,2-DIFLUORO-2-(2-PYRIDINYL)ETHYL]AMINO}-2-OXO-1(2H)-PYRAZINYL)-N-[(2-FLUORO-6-PYRIDINYL)METHYL]ACETAMIDE(db);
  • 2-NAPHTHALENESULFONIC ACID(db);
  • 2-[2-(4-CHLORO-PHENYLSULFANYL)-ACETYLAMINO]-3-(4-GUANIDINO-PHENYL)-PROPIONAMIDE(db);
  • 2-[N'-(4-AMINO-BUTYL)-HYDRAZINOCARBONYL]-PYRROLIDINE-1-CARBOXYLIC ACID BENZYL ESTER(db);
  • 3-(4-CHLOROPHENYL)-5-(METHYLTHIO)-4H-1,2,4-TRIAZOLE(db);
  • 3-(4-HYDROXY-PHENYL)PYRUVIC ACID(db);
  • 3-(7-DIAMINOMETHYL-NAPHTHALEN-2-YL)-PROPIONIC ACID ETHYL ESTER(db);
  • 3-AMINO-3-BENZYL-9-CARBOXAMIDE[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONE(db);
  • 3-cyclohexyl-D-alanyl-N-(3-chlorobenzyl)-L-prolinamide(db);
  • 4-(1R,3AS,4R,8AS,8BR)-[1-DIFLUOROMETHYL-2-(4-FLUOROBENZYL)-3-OXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN-4-YL]BENZAMIDINE(db);
  • 4-(2,5-DIAMINO-5-HYDROXY-PENTYL)-PHENOL(db);
  • 4-(5-BENZENESULFONYLAMINO-1-METHYL-1H-BENZOIMIDAZOL-2-YLMETHYL)-BENZAMIDINE(db);
  • 4-({[4-(3-METHYLBENZOYL)PYRIDIN-2-YL]AMINO}METHYL)BENZENECARBOXIMIDAMIDE(db);
  • 4-Iodobenzo[B]Thiophene-2-Carboxamidine(db);
  • 4-Oxo-2-Phenylmethanesulfonyl-Octahydro-Pyrrolo[1,2-a]Pyrazine-6-Carboxylic Acid [1-(N-Hydroxycarbamimidoyl)-Piperidin-4-Ylmethyl]-Amide(db);
  • 4-TERT-BUTYLBENZENESULFONIC ACID(db);
  • 4-[(3AS,4R,7R,8AS,8BR)-2-(1,3-BENZODIOXOL-5-YLMETHYL)-7-HYDROXY-1,3-DIOXODECAHYDROPYRROLO[3,4-A]PYRROLIZIN-4-YL]BENZENECARBOXIMIDAMIDE(db);
  • 4-[3-(4-CHLOROPHENYL)-1H-PYRAZOL-5-YL]PIPERIDINE(db);
  • 5-(DIMETHYLAMINO)-1-NAPHTHALENESULFONIC ACID(DANSYL ACID)(db);
  • 6-(2-HYDROXY-CYCLOPENTYL)-7-OXO-HEPTANAMIDINE(db);
  • 6-CARBAMIMIDOYL-2-[2-HYDROXY-5-(3-METHOXY-PHENYL)-INDAN-1-YL]-HEXANOIC ACID(db);
  • 6-CARBAMIMIDOYL-2-[2-HYDROXY-6-(4-HYDROXY-PHENYL)-INDAN-1-YL]-HEXANOIC ACID(db);
  • 6-CHLORO-1-(2-{[(5-CHLORO-1-BENZOTHIEN-3-YL)METHYL]AMINO}ETHYL)-3-[(2-PYRIDIN-2-YLETHYL)AMINO]-1,4-DIHYDROPYRAZIN-2-OL(db);
  • 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine(db);
  • AC-(D)PHE-PRO-BOROHOMOLYS-OH(db);
  • AC-(D)PHE-PRO-BOROHOMOORNITHINE-OH(db);
  • AC-(D)PHE-PRO-BOROLYS-OH(db);
  • Antihemophilic Factor(db);
  • Argatroban(db);
  • BENZOTHIAZOLE(db);
  • Beta-(2-Naphthyl)-Alanine(db);
  • beta-phenyl-D-phenylalanyl-N-propyl-L-prolinamide(db);
  • Bivalirudin(db);
  • Coagulation Factor IX(db);
  • CRA_8696(db);
  • D-leucyl-N-(3-chlorobenzyl)-L-prolinamide(db);
  • D-leucyl-N-(4-carbamimidoylbenzyl)-L-prolinamide(db);
  • D-phenylalanyl-N-(3-chlorobenzyl)-L-prolinamide(db);
  • D-phenylalanyl-N-(3-fluorobenzyl)-L-prolinamide(db);
  • D-phenylalanyl-N-(3-methylbenzyl)-L-prolinamide(db);
  • D-phenylalanyl-N-benzyl-L-prolinamide(db);
  • D-phenylalanyl-N-[(1S)-4-{[amino(iminio)methyl]amino}-1-(chloroacetyl)butyl]-L-prolinamide(db);
  • D-phenylalanyl-N-{4-[amino(iminio)methyl]benzyl}-L-prolinamide(db);
  • Dabigatran etexilate(db);
  • Drotrecogin alfa(db);
  • Gamma-Carboxy-Glutamic Acid(db);
  • Hemi-Babim(db);
  • Hirulog(db);
  • Lepirudin(db);
  • Lysophosphotidylserine(db);
  • Menadione(db);
  • methyl L-phenylalaninate(db);
  • METHYL-PHE-PRO-AMINO-CYCLOHEXYLGLYCINE(db);
  • N-(3-chlorobenzyl)-1-(4-methylpentanoyl)-L-prolinamide(db);
  • N-(4-carbamimidoylbenzyl)-1-(3-phenylpropanoyl)-L-prolinamide(db);
  • N-(4-carbamimidoylbenzyl)-1-(4-methylpentanoyl)-L-prolinamide(db);
  • N-(5-CHLORO-BENZO[B]THIOPHEN-3-YLMETHYL)-2-[6-CHLORO-OXO-3-(2-PYRIDIN-2-YL-ETHYLAMINO)-2H-PYRAZIN-1-YL]-ACETAMIDE(db);
  • N-ALLYL-5-AMIDINOAMINOOXY-PROPYLOXY-3-CHLORO-N-CYCLOPENTYLBENZAMIDE(db);
  • N-cycloheptylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide(db);
  • N-cyclooctylglycyl-N-(4-carbamimidoylbenzyl)-L-prolinamide(db);
  • N-ETHYL-N-ISOPROPYL-3-METHYL-5-{[(2S)-2-(PYRIDIN-4-YLAMINO)PROPYL]OXY}BENZAMIDE(db);
  • N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]-4-METHOXY-2,3,6-TRIMETHYLBENZENESULFONAMIDE(db);
  • N-[(2R,3S)-3-AMINO-2-HYDROXY-4-PHENYLBUTYL]NAPHTHALENE-2-SULFONAMIDE(db);
  • N-[2-(carbamimidamidooxy)ethyl]-2-{6-cyano-3-[(2,2-difluoro-2-pyridin-2-ylethyl)amino]-2-fluorophenyl}acetamide(db);
  • N-[2-({[amino(imino)methyl]amino}oxy)ethyl]-2-{6-chloro-3-[(2,2-difluoro-2-phenylethyl)amino]-2-fluorophenyl}acetamide(db);
  • N-{2,2-DIFLUORO-2-[(2R)-PIPERIDIN-2-YL]ETHYL}-2-[2-(1H-1,2,4-TRIAZOL-1-YL)BENZYL][1,3]OXAZOLO[4,5-C]PYRIDIN-4-AMINE(db);
  • N-{3-METHYL-5-[2-(PYRIDIN-4-YLAMINO)-ETHOXY]-PHENYL}-BENZENESULFONAMIDE(db);
  • N4-(N,N-DIPHENYLCARBAMOYL)-AMINOGUANIDINE(db);
  • N7-BUTYL-N2-(5-CHLORO-2-METHYLPHENYL)-5-METHYL[1,2,4]TRIAZOLO[1,5-A]PYRIMIDINE-2,7-DIAMINE(db);
  • Proflavine(db);
  • Suramin(db);
  • TRANS-4-(GUANIDINOMETHYL)-CYCLOHEXANE-L-YL-D-3-CYCLOHEXYLALANYL-L-AZETIDINE-2-YL-D-TYROSINYL-L-HOMOARGININAMIDE(db);
  • Ximelagatran(db);
  • [PHENYLALANINYL-PROLINYL]-[2-(PYRIDIN-4-YLAMINO)-ETHYL]-AMINE(db);
  • [[CYCLOHEXANESULFONYL-GLYCYL]-3[PYRIDIN-4-YL-AMINOMETHYL]ALANYL]PIPERIDINE(db);
  • {(2S)-1-[N-(tert-butoxycarbonyl)glycyl]pyrrolidin-2-yl}methyl (3-chlorophenyl)acetate(db)

    Associated Genetic Diseases:

  • Dysprothrombinemia(Pd);
  • Hyperprothrombinemia(Pd);
  • Hypoprothrombinemia(Pd);
  • Prothrombin barcelona(Pd);
  • Prothrombin Denver II(Pd);
  • Prothrombin Himi-I(Pd);
  • Prothrombin Quick I(Pd);
  • Prothrombin Quick II(Pd);
  • Prothrombin Saint-Denis(Pd);
  • Prothrombin Tokushima(Pd);
  • Prothrombin type 3(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01488 Entrez Gene ID: 2147 OMIM ID: 176930 Swissprot Accession: P00734;