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Description for Protein EZH2

enhancer of zeste homolog 2 (Drosophila)
37 total interacting proteins; 16 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SANT: SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
  • SET: SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.1.1.43
    KEGG - Orthology:
    K11430
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    ENX1; MGC9169; Enhancer of zeste 2; Enhancer of zeste 2 isoform b; Enhancer of zeste homolog 2; Enhancer of zeste 2 isoform a
    Approved Symbol:
    EZH2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 25
    Human (de-) phosphorylation sites: 25; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03342 Entrez Gene ID: 2146 OMIM ID: 601573 Swissprot Accession: Q15910;