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Description for Protein ALAS1

aminolevulinate, delta-, synthase 1
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Delta-aminolevulinate synthase (ALAS; EC 2.3.1.37) catalyzes the condensation of glycine with succinyl-CoA to form delta-aminolevulinic acid. This nuclear-encoded mitochondrial enzyme is the first and rate-limiting enzyme in the mammalian heme biosynthetic pathway. There are 2 tissue-specific isozymes: a housekeeping enzyme encoded by the ALAS1 gene and an erythroid tissue-specific enzyme encoded by ALAS2 (MIM 301300).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
2.3.1.37
KEGG - Orthology:
K00643
KEGG - Pathway(s):
hsa00260; hsa00860; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Delta amino levulinate synthase; Delta ALA synthetase; Alas housekeeping type; 5 aminolevulinic acid synthase; ALAS; Delta aminolevulinate synthase 1; ALASH; ALAS3; EC 2.3.1.37; Migration inducing protein 4; MIG4; 5-aminolevulinate synthase, nonspecific, mitochondrial; ALAS-H; OK/SW-cl.121
Approved Symbol:
ALAS1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Glycine(db);
  • Pyridoxal Phosphate(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00505 Entrez Gene ID: 211 OMIM ID: 125290 Swissprot Accession: P13196; Q5JAM2;