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Description for Protein ALAD

aminolevulinate dehydratase
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 7/1)
(microparticles: 1; platelet: 5; secretome: 3; undefined: 1)
Summary:
The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    4.2.1.24
    KEGG - Orthology:
    K01698
    KEGG - Pathway(s):
    hsa00860; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Delta aminolevulinic acid dehydratase isoform a; Delta aminolevulinic acid dehydratase isoform b; ALADH; Porphobilinogen synthase; EC 4.2.1.24; MGC5057; Delta aminolevulinic acid dehydratase; Porphyria acute hepatic; Aminolevulinate dehydratase
    Approved Symbol:
    ALAD
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3-(2-Aminoethyl)-4-(Aminomethyl)Heptanedioic Acid(db);
  • 4,7-Dioxosebacic Acid(db);
  • 4-Oxosebacic Acid(db);
  • 5-hydroxyvaleric acid(db);
  • Aminolevulinic acid(db);
  • Beta-Mercaptoethanol(db);
  • Delta-Amino Valeric Acid(db);
  • Laevulinic Acid(db);
  • Porphobilinogen(db)

    Associated Genetic Diseases:

  • Aminolevulinate dehydratase, ALAD*1/ALAD*2 polymorphism(Pd);
  • Porphyria, acute hepatic(Pd);
  • Porphyria, acute hepatic, severe infantile-onset form(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00504 Entrez Gene ID: 210 OMIM ID: 125270 Swissprot Accession: P13716; Q6ZMU0;