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Description for Protein ERN1

endoplasmic reticulum to nucleus signaling 1
13 total interacting proteins; 9 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is the ER to nucleus signalling 1 protein, a human homologue of the yeast Ire1 gene product. This protein possesses intrinsic kinase activity and an endoribonuclease activity and it is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • PQQ: beta-propeller repeat
  • TM: Transmembrane domain
  • S_T_Y_Kinase: Protein kinase
  • unclassified specificity
  • PUG: domain in protein kinases, N-glycanases and other nuclear proteins
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1; 3.1.26.-
    KEGG - Orthology:
    K08852
    KEGG - Pathway(s):
    hsa05010
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    ER to nucleus signalling 1; IRE1P; Protein kinase/endoribonulcease; IRE1; FLJ30999; Inositol requiring 1; Endoplasmic reticulum to nucleus signalling 1 isoform 2; Endoplasmic reticulum to nucleus signalling 1 isoform 1
    Approved Symbol:
    ERN1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 04943 Entrez Gene ID: 2081 OMIM ID: 604033 Swissprot Accession: O75460;