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Description for Protein AKT2

v-akt murine thymoma viral oncogene homolog 2
21 total interacting proteins; 10 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(platelet: 5)
Summary:
This gene is a putative oncogene encoding a protein belonging to a subfamily of serine/threonine kinases containing SH2-like (Src homology 2-like) domains. The gene was shown to be amplified and overexpressed in 2 of 8 ovarian carcinoma cell lines and 2 of 15 primary ovarian tumors. Overexpression contributes to the malignant phenotype of a subset of human ductal pancreatic cancers. The encoded protein is a general protein kinase capable of phophorylating several known proteins. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • PH: Pleckstrin homology domain.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K04456
    KEGG - Pathway(s):
    hsa04010; hsa04012; hsa04062; hsa04150; hsa04210; hsa04370; hsa04510; hsa04530; hsa04620; hsa04630; hsa04660; hsa04662; hsa04664; hsa04666; hsa04722; hsa04910; hsa04914; hsa04920; hsa05142; hsa05200; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05218; hsa05220; hsa05221; hsa05222; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Oncogene AKT2; RAC PK beta; Protein kinase Akt 2; PKB beta; Rac protein kinase beta; PRKBB; RAC BETA; PKBBETA; RAC-beta serine/threonine-protein kinase; EC 2.7.11.1
    Approved Symbol:
    AKT2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 12
    Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 38
    Human phosphorylation targets: 13; Predicted platelet targets: 25
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE(db);
  • 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE(db);
  • ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE(db);
  • N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide(db)

    Associated Genetic Diseases:

  • Diabetes mellitus, type II(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01262 Entrez Gene ID: 208 OMIM ID: 164731 Swissprot Accession: P31751;