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Description for Protein ERCC5

excision repair cross-complementing rodent repair deficiency, complementation group 5
11 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Excision repair cross-complementing rodent repair deficiency, complementation group 5 (xeroderma pigmentosum, complementation group G) is involved in excision repair of UV-induced DNA damage. Mutations cause Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been described, but the biological validity of all variants has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • XPGI: Xeroderma pigmentosum G I-region
  • HHH2: Helix-hairpin-helix class 2 (Pol1 family) motifs
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10846
    KEGG - Pathway(s):
    hsa03420
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    UV damage excision repair of UV 135; UVDR; ERCM2; RAD2; XPGC; XPG; OTTHUMP00000064902; XPG complementing protein; Xeroderma pigmentosum complementation group G
    Approved Symbol:
    ERCC5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 25
    Human (de-) phosphorylation sites: 25; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Xeroderma pigmentosum, group G(Pd);
  • Xeroderma pigmentosum/Cockayne syndrome complex(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00595 Entrez Gene ID: 2073 OMIM ID: 133530 Swissprot Accession: P28715;